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Tamsulosin (hydrochloride) (Standard)

Tamsulosin (hydrochloride) (Standard) is the analytical standard of Tamsulosin hydrochloride. Tamsulosin hydrochloride ((R) - (-) -YM12617 free base) is an orally active antagonist of α1-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

106463-17-6

Product Name Alternative

(R) - (-) -YM12617 (Standard) ; LY253351 (Standard)

UNSPSC

12352005

Target

Adrenergic Receptor; Apoptosis; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/tamsulosin-hydrochloride-standard.html

Smiles

O=S(C1=CC(C[C@H](NCCOC2=CC=CC=C2OCC)C)=CC=C1OC)(N)=O.Cl

Molecular Formula

C20H29ClN2O5S

Molecular Weight

444.97

References & Citations

[1]Christopher Chapple, et al. Tamsulosin: an overview. World J Urol. 2002 Apr;19 (6) :397-404.|[2]Rak A, et al. Arylsulfonamide derivatives of (aryloxy) ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity. Bioorg Med Chem. 2016 Nov 1;24 (21) :5582-5591. |[3]Sun L, et al. Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells. Bioengineered. 2021 Dec;12 (1) :5184-5194. |[4]Ida Y, et al. The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner. Bioengineering (Basel) . 2022 Oct 14;9 (10) :556.|[5]Youm Y H, et al. Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin. Journal of the Korean Continence Society, 2006, 10 (2) : 132-139. |[6]Holanda VAD, et al. Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids. Brain Res Bull. 2022 Jan;178:29-36.|[7]Kim SE, et al. Effects of Tamsulosin on Urinary Bladder Function and Neuronal Activity in the Voiding Centers of Rats with Cyclophosphamide-induced Overactive Bladder. Int Neurourol J. 2012 Mar;16 (1) :13-22. |[8]Alabdali H H, et al. Study the anti-inflammatory effects of tamsulosin by the evaluation of inflammatory cells and lung histopathology in an airway inflammation model in rats. Bulletin of Pharmaceutical Sciences. Assiut, 2023, 46 (1) : 633-645.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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