αvβ6-IN-1

αvβ6-IN-1 (compound 28) is a potent and orally active αvβ6 integrin inhibitor with a pIC50 value of 8.1. αvβ6-IN-1 has the potential for the research of idiopathic pulmonary fibrosis[1].

Product Specifications

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/αvβ6-in-1.html

Smiles

COC1=C(C)C=C(C(CC(O)=O)CN2CC(C(F)(CCC3=NC4=C(CCCN4)C=C3)F)C2)C=N1

Molecular Formula

C25H32F2N4O3

Molecular Weight

474.54

References & Citations

[1]Hryczanek HF, et al. Core Modifications of GSK3335103 toward Orally Bioavailable αvβ6 Inhibitors with Improved Synthetic Tractability. J Med Chem. 2024 Oct 17.