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N-Desalkylflurazepam (Standard)

N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively[1][2].

Product Specifications

CAS Number

2886-65-9

Product Name Alternative

Norfludiazepam (Standard)

UNSPSC

12352005

Target

Calcium Channel; Reference Standards

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-desalkylflurazepam-standard.html

Smiles

O=C1NC2=C(C(C3=C(F)C=CC=C3)=NC1)C=C(Cl)C=C2

Molecular Formula

C15H10ClFN2O

Molecular Weight

288.70

References & Citations

[1]J J Kulikowski, et al. Are the amplitudes of visual evoked potentials sensitive indices of hangover effects after repeated doses of benzodiazepines? Psychopharmacology Suppl. 1984;1:154-64.|[2]Damien E Earl, et al. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther. 2011 Apr;337 (1) :301-11.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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