Cyclosporin A-d4
Product Specifications
UNSPSC Description
Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad
Target Antigen
Antibiotic; Complement System; Isotope-Labeled Compounds; Phosphatase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Purity
99.20
Solubility
DMSO : 62.5 mg/mL (ultrasonic)|Ethanol : 50 mg/mL (ultrasonic)
Smiles
C[C@H](C/C=C([2H])/C([2H])([2H])[2H])[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)O
Molecular Weight
1206.64
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Handschumacher RE, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science. 1984 Nov 2;226(4674):544-7.;Liu J, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991 Aug 23;66(4)
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal PHF13 Antibody [DyLight 405]](https://cdn.genprice.uk/genprice/genprice2.png)
