Profadol (hydrochloride)

Profadol (CI-572) hydrochloride is a potent analgesic agent. Profadol is a µ-opioid receptor (MOR) agonist. Profadol hydrochloride activates the γ-aminobutyric acid (GABA) receptors and inhibits the N-methyl-D-aspartate (NMDA) receptor. Profadol increases the mRNA and protein expression of MOR[1][2].

Product Specifications

CAS Number

[2324-94-9]

Product Name Alternative

CI-572 (hydrochloride)

UNSPSC

12352005

Target

GABA Receptor; iGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/profadol-hydrochloride.html

Smiles

OC1=CC=CC(C2(CCC)CN(CC2)C)=C1.Cl

Molecular Formula

C14H22ClNO

Molecular Weight

255.78

References & Citations

[1]Beaver WT, et al. A comparison of the analgesic effects of profadol and morphine in patients with cancer. Clin Pharmacol Ther. 1969 May-Jun;10 (3) :314-9.|[2]Li Z, et al. Propofol increases µ-opioid receptor expression in SH-SY5Y human neuroblastoma cells. Mol Med Rep. 2012 Dec;6 (6) :1333-6.