Profadol (hydrochloride)
Profadol (CI-572) hydrochloride is a potent analgesic agent. Profadol is a µ-opioid receptor (MOR) agonist. Profadol hydrochloride activates the γ-aminobutyric acid (GABA) receptors and inhibits the N-methyl-D-aspartate (NMDA) receptor. Profadol increases the mRNA and protein expression of MOR[1][2].
Product Specifications
CAS Number
2324-94-9
Product Name Alternative
CI-572 (hydrochloride)
UNSPSC
12352005
Target
GABA Receptor; iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/profadol-hydrochloride.html
Smiles
OC1=CC=CC(C2(CCC)CN(CC2)C)=C1.Cl
Molecular Formula
C14H22ClNO
Molecular Weight
255.78
References & Citations
[1]Beaver WT, et al. A comparison of the analgesic effects of profadol and morphine in patients with cancer. Clin Pharmacol Ther. 1969 May-Jun;10 (3) :314-9.|[2]Li Z, et al. Propofol increases µ-opioid receptor expression in SH-SY5Y human neuroblastoma cells. Mol Med Rep. 2012 Dec;6 (6) :1333-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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