BAY-9835
BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis[1].
Product Specifications
CAS Number
[3032487-31-0]
UNSPSC
12352005
Target
ADAMTS
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bay-9835.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(F)C(F)=C1C2=CC=C(C(F)(F)F)C=C2)NC[C@@](C(N3)=O)(C4=CC=NN4C)NC3=O
Molecular Formula
C22H16F5N5O3
Molecular Weight
493.39
References & Citations
[1]Daniel Meibom, et al. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. J Med Chem. 2024 Feb 22;67 (4) :2907-2940.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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