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Z-LLY-FMK

Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation. Z-LLY-FMK reduces parasite burden in mice challenged with Taenia crassiceps cysts. Z-LLY-FMK can be used for the study of cysticercosis[1][2][3].

Product Specifications

CAS Number

133410-84-1

Product Name Alternative

Calpain Inhibitor IV

UNSPSC

12352005

Target

Apoptosis; Parasite; Proteasome

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-lly-fmk.html

Purity

98.65

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(CF)[C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)CC(C=C2)=CC=C2O

Molecular Formula

C30H40FN3O6

Molecular Weight

557.65

References & Citations

[1]Sheen-Chen SM, et al. Z-LLY-FMK can attenuate hepatocyte apoptosis after bile duct ligation in rat. Dig Dis Sci. 2008 Nov;53 (11) :2975-9. |[2]Baig S, et al. Cysteine proteinase inhibitors in murine cysticercosis. Antimicrob Agents Chemother. 2006 Aug;50 (8) :2886-8. |[3]Kashio Y, et al. Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol. 2003 Apr 1;170 (7) :3631-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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