Ceftiofur (sodium) (Standard)

Ceftiofur sodium (Standard) is the analytical standard of Ceftiofur sodium (HY-B0898) . This product is intended for research and analytical applications. Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

Product Specifications

CAS Number

[104010-37-9]

Product Name Alternative

Sodium ceftiofur (Standard)

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ceftiofur-sodium-standard.html

Purity

98.18

Smiles

O=C(O[Na])C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O

Molecular Formula

C19H16N5NaO7S3

Molecular Weight

545.54

Precautions

H317, H334

References & Citations

[1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.