Eicosapentaenoic acid ethyl ester

Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats[1][2][3].

Product Specifications

CAS Number

[86227-47-6]

Product Name Alternative

EPA ethyl ester; Ethyl eicosapentaenoate; AMR101

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Eicosapentaenoic-acid-ethyl-ester.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC)=O

Molecular Formula

C22H34O2

Molecular Weight

330.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Jacobson TA. A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial. Expert Rev Cardiovasc Ther. 2012 Jun;10 (6) :687-695.|[2]Makino M, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001 Nov;171 (2) :259-65.|[3]Pérez-Echarri N, et al. Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats. J Nutr Biochem. 2009 Sep;20 (9) :705-14.