Skullcapflavone I

Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1].

Product Specifications

CAS Number

[41060-16-6]

Product Name Alternative

Panicolin

UNSPSC

12352005

Target

Elastase; MicroRNA

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/skullcapflavone-i.html

Purity

99.30

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=CC=CC=C2O)OC3=C(OC)C(OC)=CC(O)=C13

Molecular Formula

C17H14O6

Molecular Weight

314.29

References & Citations

[1]Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72 (5) :557-570.|[2]Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46 (5) :821-830.