Skullcapflavone I
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and elastase enzyme with IC50s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a[1].
Product Specifications
CAS Number
[41060-16-6]
Product Name Alternative
Panicolin
UNSPSC
12352005
Target
Elastase; MicroRNA
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/skullcapflavone-i.html
Purity
99.30
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=CC=C2O)OC3=C(OC)C(OC)=CC(O)=C13
Molecular Formula
C17H14O6
Molecular Weight
314.29
References & Citations
[1]Yang B, et al. Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: In vitro and in silico Studies. J Oleo Sci. 2023;72 (5) :557-570.|[2]Cui J, et al. Skullcapflavone I has a potent anti-pancreatic cancer activity by targeting miR-23a. Biofactors. 2020 Sep;46 (5) :821-830.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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