MMP-9-IN-9

MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects[1].

Product Specifications

CAS Number

[206549-55-5]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mmp-9-in-9.html

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(CN(CC)CC)=CC(C)=C1N(S(=O)(C2=CC=C(C=C2)OC)=O)CC3=CC=CC=C3)NO

Molecular Formula

C27H33N3O5S

Molecular Weight

511.63

References & Citations

[1]Eun-Jung Lee, et al. Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-α Release from Activated Microglia and TNF-α Converting Enzyme Activity. Biomol Ther (Seoul) . 2014 Sep;22 (5) :414-9.|[2]J I Levin, et al. The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1 (1) groups. Bioorg Med Chem Lett. 2001 Aug 20;11 (16) :2189-92.