(8R,9S) -Talazoparib

(8R,9S) -Talazoparib ((8R,9S) -BMN-673) is an enantiomer of Talazoparib. (8R,9S) -Talazoparib is an PARP1 inhibitor, with an IC50 of 144 nM[1].

Product Specifications

CAS Number

[1207456-00-5]

Product Name Alternative

(8R,9S) -BMN-673; (8R,9S) -LT-673

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BMN-673-8R,9S.html

Purity

98.28

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1NN=C2C3=C1C=C(F)C=C3N[C@@H](C4=CC=C(F)C=C4)[C@@H]2C5=NC=NN5C

Molecular Formula

C19H14F2N6O

Molecular Weight

380.35

Precautions

H315, H319, H335

References & Citations

[1]Wang B, et al. Discovery and Characterization of (8S,9R) -5-Fluoro-8- (4-fluorophenyl) -9- (1-methyl-1H-1,2,4-triazol-5-yl) -2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly (ADP-