(8R,9S) -Talazoparib
(8R,9S) -Talazoparib ((8R,9S) -BMN-673) is an enantiomer of Talazoparib. (8R,9S) -Talazoparib is an PARP1 inhibitor, with an IC50 of 144 nM[1].
Product Specifications
CAS Number
1207456-00-5
Product Name Alternative
(8R,9S) -BMN-673; (8R,9S) -LT-673
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BMN-673-8R,9S.html
Purity
98.28
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1NN=C2C3=C1C=C(F)C=C3N[C@@H](C4=CC=C(F)C=C4)[C@@H]2C5=NC=NN5C
Molecular Formula
C19H14F2N6O
Molecular Weight
380.35
Precautions
H315, H319, H335
References & Citations
[1]Wang B, et al. Discovery and Characterization of (8S,9R) -5-Fluoro-8- (4-fluorophenyl) -9- (1-methyl-1H-1,2,4-triazol-5-yl) -2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly (ADP-
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Available Sizes
Frequently Asked Questions
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