Nitrovin

Nitrovin is an antibacterial growth promoter. Nitrovin induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells[1].

Product Specifications

CAS Number

[804-36-4]

Product Name Alternative

Difurazon

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Bacterial; TrxR

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nitrovin.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CC=C(/C=C/C(/C=C/C2=CC=C([N+]([O-])=O)O2)=N\NC(N)=N)O1)[O-]

Molecular Formula

C14H12N6O6

Molecular Weight

360.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Zhao L, et al. Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1) . Biochem Pharmacol. 2023 Apr;210:115487.