Nitrovin
Nitrovin is an antibacterial growth promoter. Nitrovin induces ROS-mediated non-apoptotic and apoptotic-like cell death by targeting TrxR1. Nitrovin has anticancer activity, with IC50 values of 1.31-6.60 μM for tumor and normal cells[1].
Product Specifications
CAS Number
804-36-4
Product Name Alternative
Difurazon
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Bacterial; TrxR
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/nitrovin.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC=C(/C=C/C(/C=C/C2=CC=C([N+]([O-])=O)O2)=N\NC(N)=N)O1)[O-]
Molecular Formula
C14H12N6O6
Molecular Weight
360.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhao L, et al. Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1) . Biochem Pharmacol. 2023 Apr;210:115487.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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