TCS2002

TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease[1].

Product Specifications

CAS Number

[1005201-24-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tcs2002.html

Purity

99.80

Solubility

DMSO : 34 mg/mL (ultrasonic; warming)

Smiles

O=S(C)C1=CC=C(C=C1)C2=COC3=CC=C(C4=NN=C(C)O4)C=C23

Molecular Formula

C18H14N2O3S

Molecular Weight

338.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Morihisa Saitoh, et al. 2-{3-[4- (Alkylsulfinyl) phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability. J Med Chem. 2009 Oct 22;52 (20) :6270-86.