CLM3
Product Specifications
UNSPSC Description
CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways[1].
Target Antigen
Apoptosis; EGFR; RET; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clm3.html
Smiles
C[C@@H](NC1=C2C(N(CCC3=CC=CC=C3)N=C2)=NC=N1)C4=CC=CC=C4
Molecular Weight
343.42
References & Citations
[1]Bocci G, et al. Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. Biochem Pharmacol. 2011 Jun 1;81(11):1309-16.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164413/CLM3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164413/
Clinical Information
No Development Reported
CAS Number
1312024-59-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
