CLM3

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704) . These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways[1].

Product Specifications

CAS Number

[1312024-59-1]

UNSPSC

12352005

Target

Apoptosis; EGFR; RET; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clm3.html

Smiles

C[C@@H](NC1=C2C(N(CCC3=CC=CC=C3)N=C2)=NC=N1)C4=CC=CC=C4

Molecular Formula

C21H21N5

Molecular Weight

343.42

References & Citations

[1]Bocci G, et al. Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells. Biochem Pharmacol. 2011 Jun 1;81 (11) :1309-16.