Dimethyl L-glutamate

Dimethyl L-glutamate (Dimethyl glutamate), a membrane-permeable analog of Glutamate, can stimulate insulin release induced by Glucose. Dimethyl L-glutamate suppresses the KATP channel activities. Dimethyl L-glutamate inhibits E. gracilis growth and causes abnormal cell division. Dimethyl L-glutamate can be used in the research of diabetes, glucose transport, phosphorylation, and further metabolism[1][2][3][4].

Product Specifications

CAS Number

[6525-53-7]

Product Name Alternative

Dimethyl glutamate

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Bacterial; Potassium Channel

Type

Peptides

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dimethyl-l-glutamate.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CCC(OC)=O)C(OC)=O

Molecular Formula

C7H13NO4

Molecular Weight

175.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]J Cancelas, et al. Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats. Int J Mol Med. 2001 Nov;8 (5) :531-2. |[2]Sener A, et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology-Endocrinology and Metabolism, 1994, 267 (4) : E573-E584. |[3]I S Owens, et al. Induction of abnormal cell division in Euglena gracilis by glutamic diethyl ester. J Protozool. 1969 May;16 (2) :211-5. |[4]Hidenori Katsuta, et al. Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 beta cells. Biochem Biophys Res Commun. 2003 Nov 21;311 (3) :660-4.