NL-103
Product Specifications
UNSPSC Description
NL-103 is an inhibitor of histone deacetylases (HDACs) and Hedgehog, with the IC50 values of 21.3 nM, 57 nM, 74 nM, and 680 nM for HDAC1, HDAC2, HDAC3, and HDAC6, respectively. NL-103 can downregulate the expression of Gli2. NL-103 can be used in anti-cancer research[1].
Target Antigen
Gli; HDAC; Hedgehog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nl-103.html
Smiles
O=C(C1=CN=C(NCCCCCCC(NO)=O)C=C1)NC2=CC=C(C(NC(C3=CC(Cl)=CC=C3)=O)=C2)Cl
Molecular Weight
544.43
References & Citations
[1]Zhao J, et al. NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. Pharmacol Res Perspect. 2014 Jun;2(3):e00043.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12487/NL-103-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12487/
Clinical Information
No Development Reported
CAS Number
1788896-33-2
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