E1R

E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1].

Product Specifications

CAS Number

[1301211-78-8]

Product Name Alternative

MK-0869; MK-869; L-754030

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e1r.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CN1C(C[C@@H]([C@@H]1C)C2=CC=CC=C2)=O)N

Molecular Formula

C13H16N2O2

Molecular Weight

232.28

References & Citations

[1]Zvejniece L, et al. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br J Pharmacol. 2014 Feb;171 (3) :761-71.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Sigma 1 Receptor

Available Sizes

Curated Selection

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