ICAM1 Recombinant Rabbit Monoclonal Antibody [JE77-69]
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Intercellular adhesion molecule 1 ICAM-1 ICAM1 Major group rhinovirus receptor CD54
Swiss Prot
P13597 Mouse
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant protein within Mouse ICAM1 aa 1-300 / 537.
Isotype
IgG
Clone
JE77-69
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Mouse kidney tissue lysate, mouse spleen tissue lysate, mouse lung tissue lysate, mouse liver tissue, mouse lung tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:10,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 59 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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