Bempedoic acid-d4
Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].
Product Specifications
CAS Number
2408131-70-2
Product Name Alternative
ETC-1002-d4; ESP-55016-d4
UNSPSC
12352211
Target
AMPK; ATP Citrate Lyase
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C(C)(C)CCCCC([2H])([2H])C(O)C([2H])([2H])CCCCC(C)(C)C(O)=O)=O
Molecular Formula
C19H32D4O5
Molecular Weight
348.51
References & Citations
[1]Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54 (1) :134-51.|[2]Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54 (8) :2095-108. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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