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A 77-01

A 77-01 is a potent inhibitor of transforming growth factor (TGF) -β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].

Product Specifications

CAS Number

607737-87-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/a-77-01.html

Purity

99.92

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=CC=CC(C2=NNC=C2C3=CC=NC4=CC=CC=C34)=N1

Molecular Formula

C18H14N4

Molecular Weight

286.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96 (11) :791-800.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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