1-Naphthyl PP1

1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1][2][3].

Product Specifications

CAS Number

[221243-82-9]

Product Name Alternative

1-NA-PP 1

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

PKD; Src

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-Naphthyl-PP1.html

Purity

98.96

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C

Molecular Formula

C19H19N5

Molecular Weight

317.39

Precautions

H315, H319, H320

References & Citations

[1]Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407 (6802) :395-401.|[2]Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8 (9) :e75601.|[3]Maiya R, et al. Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology. 2016 Aug;107:40-48.