1-Naphthyl PP1
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1][2][3].
Product Specifications
CAS Number
221243-82-9
Product Name Alternative
1-NA-PP 1
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
PKD; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-Naphthyl-PP1.html
Purity
98.96
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C
Molecular Formula
C19H19N5
Molecular Weight
317.39
Precautions
H315, H319, H320
References & Citations
[1]Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407 (6802) :395-401.|[2]Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8 (9) :e75601.|[3]Maiya R, et al. Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology. 2016 Aug;107:40-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKD1; PKD2; PKD3
Available Sizes
Frequently Asked Questions
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