PD-166866
PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
Product Specifications
CAS Number
[192705-79-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; FGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PD166866.html
Purity
99.75
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3
Molecular Formula
C20H24N6O3
Molecular Weight
396.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286 (1) :569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3- (3,5-Dimethoxyphenyl) -1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43 (22) :4200-4211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Available Sizes
Curated Selection
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