A2AAR/hMAO-B-IN-1
A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) andMAO-B (Ki: 39.5 nM, human) . A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD) [1].
Product Specifications
CAS Number
[1439488-21-7]
UNSPSC
12352005
Target
Adenosine Receptor; Monoamine Oxidase
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a2aar-hmao-b-in-1.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C1SC(NC(CCCC2=CC=CC=C2)=O)=NC3=C1C=CC=C3
Molecular Formula
C18H16N2O2S
Molecular Weight
324.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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