WDR5-IN-5
WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5) . WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value [1].
Product Specifications
CAS Number
[2417012-26-9]
UNSPSC
12352005
Target
WDR5
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wdr5-in-5.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N([C@@H](C2CC2)C3=NC=CC(C)=C3)CCC4=C1C=C(CN5C=CN=C5)C=C4C6=CN(CC)N=C6C(F)(F)F
Molecular Formula
C29H29F3N6O
Molecular Weight
534.58
References & Citations
[1]Teuscher KB, et al. Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J Med Chem. 2022 Apr 28. 65 (8) :6287-6312.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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