U-PAR rabbit pAb
Function: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. similarity: Contains 3 UPAR/Ly6 domains. subunit: Monomer (Probable). Interacts with MRC2.
Product Specifications
Background
Function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form., similarity:Contains 3 UPAR/Ly6 domains., subunit:Monomer (Probable) . Interacts with MRC2.
UniProt
Q03405
Swiss Prot
Q03405
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human U-PAR
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane ; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted .
Other Product Names
Urokinase plasminogen activator surface receptor (U-PAR; uPAR; Monocyte activation antigen Mo3; CD antigen CD87)
Gene ID (Human)
5329
Available Sizes
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