Dapivirine-d4

Dapivirine-d4 (TMC120-d4) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI) . Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2][3].

Product Specifications

CAS Number

[1309283-15-5]

Product Name Alternative

TMC120-d4; R147681-d4

UNSPSC

12352005

Target

Apoptosis; Autophagy; HIV; Isotope-Labeled Compounds; Reverse Transcriptase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; Others

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

N#CC1=C([2H])C([2H])=C(NC2=NC=CC(NC3=C(C)C=C(C)C=C3C)=N2)C([2H])=C1[2H]

Molecular Formula

C20H15D4N5

Molecular Weight

333.42

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9 (1) :117-128.|[3]Bríd Devlin, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8.|[4]Yven Van Herrewege, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48 (1) :337-9.|[5]Michael E Halwes, et al. Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci. 2016 Oct 10;93:410-8.