Pepluanin A

Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport[1]</sup.

Product Specifications

CAS Number

[670257-89-3]

UNSPSC

12352005

Target

P-glycoprotein

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pepluanin-a.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CN=C1)O[C@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)C(C)(C)/C=C/[C@H](C)[C@H](OC(C)=O)[C@](C[C@@](C)(OC(C)=O)[C@@H]3OC(C4=CC=CC=C4)=O)(O)[C@@]3([H])[C@@H](OC(C)=O)C2=C

Molecular Formula

C43H51NO15

Molecular Weight

821.86

References & Citations

[1]Corea G, et al. Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A. J Med Chem. 2004;47 (4) :988-992.