Pepluanin A
Product Specifications
UNSPSC Description
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport[1]</sup.
Target Antigen
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pepluanin-a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)O[C@H]([C@H](OC(C)=O)[C@H]2OC(C)=O)C(C)(C)/C=C/[C@H](C)[C@H](OC(C)=O)[C@](C[C@@](C)(OC(C)=O)[C@@H]3OC(C4=CC=CC=C4)=O)(O)[C@@]3([H])[C@@H](OC(C)=O)C2=C
Molecular Weight
821.86
References & Citations
[1]Corea G, et al. Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A. J Med Chem. 2004;47(4):988-992.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N7332/Pepluanin-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N7332/
Clinical Information
No Development Reported
CAS Number
670257-89-3
Curated Selection
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