SHP2-IN-31
SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models[1].
Product Specifications
CAS Number
2411321-35-0
UNSPSC
12352005
Target
ERK; SHP2
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-31.html
Smiles
N[C@H]1C2(CO[C@H]1C)CCN(C3=C(C(N(C4=C(C(Cl)=CC=C4)Cl)C(C)=N3)=O)C)CC2
Molecular Formula
C21H26Cl2N4O2
Molecular Weight
437.36
References & Citations
[1]James P. Stice, et al. Abstract P207: BBP-398, a potent, small molecule inhibitor of SHP2, enhances the response of established NSCLC xenografts to KRASG12C and mutEGFR inhibitors. Mol Cancer Ther (2021) 20 (12_Supplement) : P207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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