ML277
ML277 (CID-53347902) is a potent and selective activator of K (v) 7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes[1][2].
Product Specifications
CAS Number
1401242-74-7
Product Name Alternative
CID-53347902
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ML277.html
Purity
98.46
Solubility
DMSO : ≥ 56 mg/mL
Smiles
O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3
Molecular Formula
C23H25N3O4S2
Molecular Weight
471.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Mattmann ME, et al. Identification of (R) -N- (4- (4-methoxyphenyl) thiazol-2-yl) -1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K (v) 7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22 (18) :5936-41.|[2]Eldstrom J, et al. ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. J Gen Physiol. 2021 Dec 6;153 (12) :e202112969.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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