ML277

ML277 (CID-53347902) is a potent and selective activator of K (v) 7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes[1][2].

Product Specifications

CAS Number

[1401242-74-7]

Product Name Alternative

CID-53347902

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ML277.html

Purity

98.46

Solubility

DMSO : ≥ 56 mg/mL

Smiles

O=C([C@@H]1N(S(=O)(C2=CC=C(C)C=C2)=O)CCCC1)NC3=NC(C4=CC=C(OC)C=C4)=CS3

Molecular Formula

C23H25N3O4S2

Molecular Weight

471.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Mattmann ME, et al. Identification of (R) -N- (4- (4-methoxyphenyl) thiazol-2-yl) -1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K (v) 7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22 (18) :5936-41.|[2]Eldstrom J, et al. ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state. J Gen Physiol. 2021 Dec 6;153 (12) :e202112969.