SOD1-Derlin-1 inhibitor-2

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1].

Product Specifications

CAS Number

[2170170-27-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sod1-derlin-1-inhibitor-2.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(N)C2=CC=C(C3=CC=CN=C3)N=C2S1)N(C4=CC=CC=C4)CC=C

Molecular Formula

C22H18N4OS

Molecular Weight

386.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9 (1) :2668.