PF-06751979

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.

Product Specifications

CAS Number

[1818339-66-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PF-06751979.html

Purity

99.23

Solubility

DMSO : 150 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

FC(F)OC1=CN=C(C(NC2=CSC([C@]34CO[C@@H](C)C[C@@]3([H])CSC(N)=N4)=N2)=O)C=C1

Molecular Formula

C18H19F2N5O3S2

Molecular Weight

455.50

Precautions

H302, H315, H319, H335

References & Citations

[1]O'Neill BT, et al. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation. J Med Chem. 2018 May 24;61 (10) :4476-4504.