Lck-IN-2
Lck-IN-2 (compound 12a) is an inhibitor of Lymphocyte-specific protein tyrosine kinase (Lck) with IC50 of 10.6 nM. Lck-IN-2 reveals efficacy in colon cancer cells with GI50s of 0.24-1.26 μM. Lck-IN-2 exhibits an apoptotic effect in Colo201 cells[1].
Product Specifications
CAS Number
2615173-24-3
UNSPSC
12352005
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lck-in-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1N2CC3=C(N(C2=O)C)N=C(N=C3)NC4=CN=C(C=C4)C)NC(C5=CC=C(C(OCC(C)C)=C5)[N+]([O-])=O)=O
Molecular Formula
C31H32N8O5
Molecular Weight
596.64
References & Citations
[1]Hyun Ji S, et al., Identification of 3,4-dihydropyrimido[4,5-d]pyrimidin-2 (1H) -one scaffolds as potent Lck inhibitors as anti-cancer agents. Bioorg Med Chem Lett. 2024 Feb 3:129645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Lck
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