PROTAC (H-PGDS) -7
PROTAC (H-PGDS) -7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM[1].
Product Specifications
CAS Number
[2761281-50-7]
UNSPSC
12352005
Target
Molecular Glues; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/protac-h-pgds-7.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CCN(C2=CC=C(NC(C3=CN=C(OC4=CC=CC=C4)N=C3)=O)C=C2)CC1)N5CCN(C6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)CC5
Molecular Formula
C40H38N8O7
Molecular Weight
742.78
References & Citations
[1]Hidetomo Yokoo, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem. 2021 Nov 11;64 (21) :15868-15882.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DP
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
