Isonicotinic acid-d4
Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid. Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus[1][2][3].
Product Specifications
CAS Number
53907-55-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate; Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection
Purity
98.12
Solubility
10 mM in DMSO
Smiles
[2H]C1=C([2H])C(C(O)=O)=C([2H])C([2H])=N1
Molecular Formula
C6HD4NO2
Molecular Weight
127.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59 (11) :6791-9.|[3]Boltz D, et al. Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells. Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618811416.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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