PF-07265807
PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer[1].
Product Specifications
CAS Number
[2412356-57-9]
UNSPSC
12352005
Target
C-Met/HGFR; TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tam-met-in-1.html
Purity
97.13
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12
Molecular Formula
C29H27F2N7O5
Molecular Weight
591.57
References & Citations
[1]Ronald Jay Hinklin, et al. PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES. WO2020047184A1 (example 1) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Axl; Mer; Tyro3
Available Sizes
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