MA-2029

MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM) . MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility[1].

Product Specifications

CAS Number

[287206-61-5]

UNSPSC

12352005

Target

Motilin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ma-2029.html

Purity

98.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C[C@H](NC)C(N(C)[C@@H](C(C)C)C(N[C@H](C(NCC)=O)CC2=CC(C(C)(C)C)=C(O)C=C2)=O)=O

Molecular Formula

C31H45FN4O4

Molecular Weight

556.71

References & Citations

[1]Sudo H, et al. Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur J Pharmacol. 2008 Mar 10;581 (3) :296-305.