S-Isopropylisothiourea (hydrobromide)

S-Isopropylisothiourea hydrobromide (S-isopropyl ITU; IPTU) is a blood-brain barrier (BBB) penetrant NOS inhibitor with IC50 values of 0.66, 0.75 and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic and porcine endothelial cell NOS. S-Isopropylisothiourea exhibits a significant blood pressure-raising effect without damaging the perfusion of vital organs and can also inhibit the late-phase pain response induced by formalin. S-Isopropylisothiourea hydrobromide is used in the researchs for hemorrhagic shock and pain response based on NOS[1][2].

Product Specifications

CAS Number

[4269-97-0]

Product Name Alternative

S-isopropyl ITU; IPTU

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/s-isopropylisothiourea-hydrobromide.html

Purity

98.0

Smiles

NC(SC(C)C)=N.Br

Molecular Formula

C4H11BrN2S

Molecular Weight

199.11

Precautions

H302, H315, H319, H335

References & Citations

[1]A Vromen, et al. Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock. J Appl Physiol (1985) . 1996 Aug;81 (2) :707-15.|[2]Handy RL, Wallace P, Moore PK. Inhibition of nitric oxide synthase by isothioureas: cardiovascular and antinociceptive effects. Pharmacol Biochem Behav. 1996 Oct;55 (2) :179-84.