UNC10245380
Product Specifications
UNSPSC Description
UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research[1][2].
Target Antigen
Akt; ERK; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc10245380.html
Smiles
ClC1=C(CNC(C2CCC(CC2)CC3C(C4=CC=CC=C4N=C3SCC(NC5=NNC(C)=C5)=O)=O)=O)C=CC=C1
Molecular Weight
578.12
References & Citations
[1]An Y, et al. In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot. Nat Commun. 2024 Jul 2;15(1):5564. |[2]Chung AH, et al. CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death. Cancer Cell Int. 2019 Feb 4;19:26.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163805/UNC10245380-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163805/
Clinical Information
No Development Reported
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