UNC10245380

Product Specifications

UNSPSC Description

UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research[1][2].

Target Antigen

Akt; ERK; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc10245380.html

Smiles

ClC1=C(CNC(C2CCC(CC2)CC3C(C4=CC=CC=C4N=C3SCC(NC5=NNC(C)=C5)=O)=O)=O)C=CC=C1

Molecular Weight

578.12

References & Citations

[1]An Y, et al. In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot. Nat Commun. 2024 Jul 2;15(1):5564. |[2]Chung AH, et al. CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death. Cancer Cell Int. 2019 Feb 4;19:26.