D- (-) -3-Phosphoglyceric acid (disodium)

D- (-) -3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D- (-) -3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase) . D- (-) -3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis[1][2][3].

Product Specifications

CAS Number

[80731-10-8]

Product Name Alternative

3-Phospho-D-glyceric acid (disodium)

UNSPSC

12352211

Hazard Statement

H315, H319, H335, H370

Target

Apoptosis; Enolase; MDM-2/p53; Phosphoglycerate Dehydrogenase (PHGDH)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/d-minus-3-phosphoglyceric-acid-disodium.html

Purity

99.43

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O[Na])[C@H](O)COP(O)(O[Na])=O

Molecular Formula

C3H5Na2O7P

Molecular Weight

230.02

Precautions

H315, H319, H335, H370

References & Citations

[1]Ramos ML, Justino LL, Gil VM, Burrows HD. NMR and DFT studies of the complexation of W (VI) and Mo (VI) with 3-phospho-D-glyceric and 2-phospho-D-glyceric acids. Dalton Trans. 2009; (43) :9616-9624. |[2]Faller LD, et al. Calorimetric studies of the role of magnesium ions in yeast enolase catalysis. Proc Natl Acad Sci U S A. 1974;71 (4) :1083-1087. |[3]Yu-Qing Wu, et al. Low glucose metabolite 3-phosphoglycerate switches PHGDH. Cell Res. 2023 Nov;33 (11) :835-850.