KOR agonist 2
KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes[1].
Product Specifications
CAS Number
3050912-29-0
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kor-agonist-2.html
Smiles
O=S(C1=CC=CC(Cl)=C1)(N(CC2=CC=CC=C2)[C@@H]3C[C@H](CN(C)C)[C@](C4=CC=CC(OC)=C4)(O)CC3)=O
Molecular Formula
C29H35ClN2O4S
Molecular Weight
543.12
References & Citations
[1]Gao Y, et al., Discovery of N'-benzyl-3-chloro-N- ((1S,3R,4R) -3- ((dimethylamino) methyl) -4-hydroxy-4- (3-methoxyphenyl) cyclohexyl) benzenesulfonamide as a novel selective KOR ligand. Eur J Med Chem. 2024 Jul 3;276:116643.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
κ Opioid Receptor/KOR
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