Cercosporamide

Cercosporamide is a highly potent, ATP-competitive PKC kinase inhibitor targeting to PKC1, with an IC50 of Ki of Mnk inhibitor.

Product Specifications

CAS Number

[131436-22-1]

Product Name Alternative

(-) -Cercosporamide

UNSPSC

12352005

Hazard Statement

H302

Target

Fungal; MNK; PKC

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; MAPK/ERK Pathway; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Cercosporamide.html

Purity

99.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C(C([C@@]23C)=C(O)C=C1O)OC2=CC(O)=C(C(C)=O)C3=O)N

Molecular Formula

C16H13NO7

Molecular Weight

331.28

Precautions

H302

References & Citations

[2]Altman JK, et al. Inhibition of Mnk kinase activity by Cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121 (18) :3675-81.|[1]Sussman A, et al. Discovery of Cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell. 2004 Aug;3 (4) :932-43.