Cercosporamide
Cercosporamide is a highly potent, ATP-competitive PKC kinase inhibitor targeting to PKC1, with an IC50 of Ki of Mnk inhibitor.
Product Specifications
CAS Number
131436-22-1
Product Name Alternative
(-) -Cercosporamide
UNSPSC
12352005
Hazard Statement
H302
Target
Fungal; MNK; PKC
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; MAPK/ERK Pathway; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Cercosporamide.html
Purity
99.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(C([C@@]23C)=C(O)C=C1O)OC2=CC(O)=C(C(C)=O)C3=O)N
Molecular Formula
C16H13NO7
Molecular Weight
331.28
Precautions
H302
References & Citations
[2]Altman JK, et al. Inhibition of Mnk kinase activity by Cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121 (18) :3675-81.|[1]Sussman A, et al. Discovery of Cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell. 2004 Aug;3 (4) :932-43.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MNK
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