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AURKA-IN-1

AURKA-IN-1 (compound 9) is an cell-active covalent AURKA inhibitor. AURKA-IN-1 is a lysine-reactive activity probe[1].

Product Specifications

UNSPSC

12352005

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aurka-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC#C)C1=CC(NC2=NNC(C3CC3)=C2)=NC(N4CCN(C(C5=CC=C(OS(=O)(F)=O)C=C5)=O)CC4)=N1

Molecular Formula

C25H25FN8O5S

Molecular Weight

568.58

References & Citations

[1]Guanghui Tang, et al. Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew Chem Int Ed Engl. 2024, 63, 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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