Phospho-IRE1 (S724) Recombinant Rabbit Monoclonal Antibody [PSH03-35]
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals (mainly the unfolded protein response). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Specifications
Product Name Alternative
Abbreviation
ERN1, IRE1
Swiss Prot
O75460 Human, Q9EQY0 Mouse
Cellular Locus
Endoplasmic reticulum membrane; nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser724 of human IRE1.
Isotype
IgG
Clone
PSH03-35
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:500 ;IHC-P: 1:500 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 110 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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