Phospho-IRE1 (S724) Recombinant Rabbit Monoclonal Antibody [PSH03-35]
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals (mainly the unfolded protein response). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ERN1, IRE1
Swiss Prot
O75460 Human, Q9EQY0 Mouse
Cellular Locus
Endoplasmic reticulum membrane; nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser724 of human IRE1.
Isotype
IgG
Clone
PSH03-35
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IF-Cell: 1:500 ;IHC-P: 1:500 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 110 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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